Home>Steel>glucose metabolite glyoxal induces senescence in

glucose metabolite glyoxal induces senescence in

Glucose metabolite glyoxal induces senescence in

Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells By Simon Asbjørn Larsen,Moustapha Kassem and Suresh IS Rattan Topics Research Article How is lipid metabolism related to senescent cells?How is lipid metabolism related to senescent cells?Thus,lipid metabolism might be responsible for the increased oxidant species in senescent cells.Key enzymes in the fatty acid synthesis pathway are known to be regulated by glucose.And high glucose could increase lipid droplets in many cell types [19],[20],[21],[22].Oxidative stress mediated by lipid metabolism contributes How is sugar related to the regulation of natural senescence?How is sugar related to the regulation of natural senescence?The involvement of sugar-mediated repression of genes in the regulation of natural senescence is less clear ( Feller and Fischer,1994 ).Regulation of Leaf Senescence by Cytokinin,Sugars,and Light Plant

What is the connection between senescence and diabetes?What is the connection between senescence and diabetes?The association between diabetes and senescence may be complex and complementary.On one hand,it is likely that the diabetic microenvironment could be permissive to the development and accumulation of senescent cells.On the other hand,senescent cells may contribute to the tissue dysfunction and comorbidities observed in type 2 diabetes.Cellular Senescence in Type 2 Diabetes A Therapeutic Opportunity Dia(PDF) CSN1S2 protein of goat milk inhibits the decrease of

CSN1S2 protein of goat milk inhibits the decrease of viability and increases the proliferation of MC3T3E1 pre-osteoblast cell in methyl glyoxal exposure(PDF) Glucose metabolite glyoxal induces senescence in Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells.pdf Available via license CC BY 4.0 Content may be subject to copyright.

1.Introduction

CMA was synthesized by the reaction of l-arginine and glyoxal,as described by Odani et al.[17] with minor modifications.In brief,l-arginine (100 mM) was incubated with glyoxal (100 mM) in a 1.0 M sodium hydrate solution for 1 week at 37°C,since approximately 50% of the l-arginine,estimated using the peak area obtained from ESI-LC-MS/MS analysis,was unmodified after the 2-day incubation.Advancements in therapeutic drugs targeting of senescence Aging leads to a high burden on society,both medically and economically.Cellular senescence plays an essential role in the initiation of aging and age-relatedAldehydo-D-galactose C6H12O6 - PubChem2021-04-17.Create.2004-09-16.Aldehydo-D-galactose is a D-galactose and an aldehydo-galactose.It is an enantiomer of an aldehydo-L-galactose.Galactose has been used in trials studying the treatment and diagnosis of Hepatitis C,Hepatic Cancer,Wilsons Disease,Diabetic Macular Oedema,and Focal Segmental Glomerulosclerosis,among others.

Alzheimer's disease alters oligodendrocytic glycolytic

brain glucose metabolism,which may affect AD onset and progression.Ketolysis has senescence-related dementia,and is clinically characterized by neu- ies have hypothesized that ketones fuel the brain under AD-induced impairments in brain glucose metabolism.2022 While impaired brainAnalysis,Distribution,and Dietary Exposure of Glyoxal Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells.Chemistry Central Journal 2012,6 (1) https://doi/10.1186/1752-153X-6-18; Lin Li,Lipeng Han,Quanyi Fu,Yuting Li,Zhili Liang,Jianyu Su,Bing Li.Atypical senescent states Metabolic stress-induced senescenceMetabolic stress,defined here as a combination of aerobic glycolysis and mitochondria dysfunction can potentially trigger a senescent state.All organisms that use aerobic glycolysis form reactive acyclic -oxoaldehydes (e.g.methylglyoxal and glyoxal) spontaneously from triosephosphates and by a wide variety of other routes (Thornalley,2009).).These dicarbonyl compounds are highly

Author Hong Li,Ling Zheng,Chao Chen,Xiaoli Liu,Wensheng ZhangPublish Year 2019TXNIP regulates AKTmediated cellular senescence by direct

Aug 31,2018·High glucose induces senescence of KO MEF cells.(a) WT and KO MEF cells were initially plated at 2 × 10 5 cells and cultured by subculturing at 3day intervals and the cell number counted at the same intervals or same passages (from P1 to P5) (n = 3).(b) The size of trypsinized MEF cells was measured for the longest diameter by microscopic images.Cellular Senescence in Type 2 Diabetes A Therapeutic Cellular senescence is a fundamental aging mechanism that has been implicated in many age-related diseases and is a significant cause of tissue dysfunction.Accumulation of senescent cells occurs during aging and is also seen in the context of obesity and diabetes.Senescent cells may play a role in type 2 diabetes pathogenesis through direct impact on pancreatic -cell function,senescence CiteSeerX RESEARCH ARTICLE Open AccessAmong various RCS is the highly reactive dicarbonyl glyoxal (GO),which is a natural physiological metabolite produced by the autooxidation of glucose,and can form covalent adducts known as advanced glycation endproducts (AGE).We have previously reported that GO accelerates ageing and causes premature senescence in normal human skin fibroblasts.

Cited by 118Publish Year 2010Author Gema Arribas-Lorenzo,Francisco J.MoralesGlyoxal-induced premature senescence in human fibroblasts.

Our present studies show that early-passage human skin fibroblasts treated with 1 mM glyoxal for 72 h undergo premature senescence in terms of enlarged cell size,inhibition of cell division,slowing down of cell growth,a decrease in the number of DNA synthesizing cells,and increased resistance to apoptosis.PMID 17460217 [Indexed for MEDLINE]Cited by 11Publish Year 2007Author Henrik Sejersen,Suresh I.S.RattanReaction of Glyoxal with 2-Deoxyguanosine,2 Glyoxal (ethanedial) is an increasingly used industrial chemical that has been found to be mutagenic in bacteria and mammalian cells.In this study,the reactions of glyoxal with 2-deoxyguanosine,2-deoxyadenosine,2-deoxycytidine,cytidine,thymidine,and calf thymus DNA have been studied in aqueous buffered solutions.The nucleoside adducts were isolated by reversed-phase liquid Cited by 21Publish Year 2014Author D Gitenay,C Wiel,H Lallet-Daher,D Vindrieux,S Aubert,L Payen,H Simonnet,D BernardSimon Asbjørn Larsen Director,Client Relations Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells Chemistry Central Journal 12.marts 2012 BACKGROUND Various by-products of the cellular metabolism,such as reactive carbonyl species (RCS) are potentially harmful to cells and tissues,and play a role in many physiological and pathological

Cited by 21Publish Year 2019Author Qingqiu Chen,Li Tang,Guang Xin,Shiyi Li,Limei Ma,Yao Xu,Manjiao Zhuang,Qiuyang Xiong,ZeliangCiteSeerX RESEARCH ARTICLE Open Access

Among various RCS is the highly reactive dicarbonyl glyoxal (GO),which is a natural physiological metabolite produced by the auto-oxidation of glucose,and can form covalent adducts known as advanced glycation endproducts (AGE).We have previously reported that GO accelerates ageing and causes premature senescence in normal human skin fibroblasts.Cited by 52Publish Year 2012Author Simon Asbjørn Larsen,Moustapha Kassem,Moustapha Kassem,Suresh Is RattanGlucose metabolite glyoxal induces senescence in Among various RCS is the highly reactive dicarbonyl glyoxal (GO),which is a natural physiological metabolite produced by the auto-oxidation of glucose,and can form covalent adducts known as advanced glycation endproducts (AGE).We have previously reported that GO accelerates ageing and causes premature senescence in normal human skin fibroblasts.Cited by 52Publish Year 2012Author Simon Asbjørn Larsen,Moustapha Kassem,Moustapha Kassem,Suresh Is RattanImages of Glucose metabolite glyoxal induces senescence in imagesGlucose metabolite glyoxal induces senescence in is the highly reactive dicarbonyl glyoxal (GO),which is a natural physiological metabolite produced by the auto-oxidation of glucose,and can form covalent adducts known as advanced glycation endproducts (AGE).We have previously reported that GO accelerates ageing and causes premature senescence in normal human skin fibroblasts.

Cited by 57Publish Year 2018Author Dominick G.A.Burton,Richard G.A.FaragherInvestigating the Glycating Effects of Glucose,Glyoxal

Investigating the Glycating Effects of Glucose,Glyoxal and Methylglyoxal on Human Sperm.Glycation is the non-enzymatic reaction between reducing sugars,such as glucose,and proteins,lipids or nucleic acids,producing Advanced Glycation End (AGE) products.AGEs,produced during natural senescence as well as through lifestyle factors such as diet and smoking,are key pathogenic compoun.Cited by 7Publish Year 2018Author Clare Nevin,Lauren McNeil,Nessar Ahmed,Chris Murgatroyd,Daniel Brison,Michael CarrollCOREGlucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cellsDefects in antioxidant defence enhance glyoxal toxicity in Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells.Chem Cent J.2012 ·Tumor heterogeneity in regard to mitochondrial metabolism,in seeming contradiction to the Warburg effect,is considered to induce the diversity in activated metabolic pathways (Fig.2).Notably,MRD in several kinds of cancers is enriched in CSCs,leading to intra-tumoral heterogeneity and poor prognosis [ 1 ,9 ,10 ,37 ].

Dicarbonyls induce senescence of human vascular

Sep 01,2017·Taken together all our results,reactive dicarbonyls in physiological concentrations and especially glyoxal as well as the combination of glyoxal and methylglyoxal have a tremendous impact on human vascular endothelial cells.They induce cellular senescence and trap cells in the GDietary Metabolites and Chronic Kidney Diseasenutrients Review Dietary Metabolites and Chronic Kidney Disease Sho Hasegawa 1,Tzu-Ming Jao 2 and Reiko Inagi 2,* 1 Division of Nephrology and Endocrinology,the University of Tokyo Graduate School of Medicine,Tokyo 113-8655,Japan; [email protected] 2 Division of CKD Pathophysiology,the University of Tokyo Graduate School of Medicine,Tokyo 113-8655,Japan;ERKs in Cancer Friends or Foes? Cancer ResearchThe extracellular signalregulated kinase ERK1 and ERK2 (ERK1/2) cascade regulates a variety of cellular processes by phosphorylating multiple target proteins.The outcome of its activation ranges from stimulation of cell survival and proliferation to triggering tumor suppressor responses such as cell differentiation,cell senescence,and apoptosis.

Frontiers Brain Senescence Caused by Elevated Levels of

Sep 18,2019·Therefore,whether and how D-galactose induces senescence by elevated levels of reactive metabolite MG remain unclear.In the current study,we investigated the underlying mechanism of D-galactose-induced brain senescence.Results showed that long-term administration of D-galactose induced memory and study impairment.Frontiers From Glucose to Lactate and Transiting Glucose and Lactate in Cancer Background.It is a well-known fact that most cancers exhibit increased rates in glucose consumption (Bose and Le,2018).This is clinically exploited by following radionuclide-labeled glucose analogs for the purpose of tumor imaging in living human beings (Feng et al.,2019).The very same cancers are also known to be major lactate producers,which is important Glucose metabolism and hexosamine pathway regulate Glucose metabolism decreases during oncogenic stress-induced senescence.Immortalized human epithelial cells expressing the inducible MEK/ER oncogene were treated or not with 4-OHT.a

Glucose metabolite glyoxal induces senescence in - CORE

Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cellsGlucose metabolite glyoxal induces senescence in - COREGlucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells .By Larsen Simon, -immortalised mesenchymal stem cell line hMSC-TERT we have observed that an exposure of cells to 0.75 mM and 1 mM GO induces irreversible cellular senescence within 3 days.Induction of senescence in hMSC-TERT was Glucose metabolite glyoxal induces senescence in Finally,the results of our current study demonstrate that the glucose metabolite GO can induce cellular senescence in stem cells similar to the stress-induced premature senescence (SIPS) model .Our in vitro model of GO-induced senescence in telomerase-immortalized human mesenchymal stem cells may be similarly utilized in ageing interventional studies.

Glucose metabolite glyoxal induces senescence in

Glucose metabolite glyoxal induces senescence in Glucose metabolite glyoxal induces senescence in Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells By Simon Asbjørn Larsen,Moustapha Kassem and Suresh IS Rattan CiteGlycine cleavage system determines the fate of pluripotent Sep 27,2019·Intriguingly,we observed that MG treatment dose-dependently induced the expression of senescence markers in V6.5 cells ,suggesting that MG may lead to ESC senescence.During MEF cell reprogramming induced by the four Yamanaka factors,supplementation with MG led to increased levels of argpyrimidine,an MG-derived AGE,and senescence markers

Glyoxal-Induced Premature Senescence in Human

Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cellsHigh Glucose Induces Bone Marrow-Derived MesenchymalMay 11,2015·Hyperglycemia was reported to cause bone marrow hematopoietic niche dysfunction,and high glucose (HG) in the cultured medium induces MSC senescence.The underlying mechanism is unclear.Here,we investigated the role of HG-induced autophagy in bone-marrow-derived mesenchymal stem cell (BMSC) senescence.HG (25 mM) increased expression of Beclin-1,Atg 5,7 and 12,Hypoxia induces senescence of bone marrow mesenchymalSystemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow (BM) and gut microbiota.Here we analyse patients with cyanotic congenital heart

JCI - Mechanisms and functions of cellular senescence

Apr 02,2018·Cellular senescence was originally identified as a stable exit from the cell cycle caused by the finite proliferative capacity of cultured human fibroblasts (1,2).Currently,senescence is considered a stress response that can be induced by a wide range of intrinsic and extrinsic insults,including oncogenic activation,oxidative and genotoxic stress,mitochondrial dysfunction,irradiation,JCI - Mechanisms and functions of cellular senescenceApr 02,2018·Cellular senescence was originally identified as a stable exit from the cell cycle caused by the finite proliferative capacity of cultured human fibroblasts (1,2).Currently,senescence is considered a stress response that can be induced by a wide range of intrinsic and extrinsic insults,including oncogenic activation,oxidative and genotoxic stress,mitochondrial dysfunction,irradiation,or L-Cysteine C3H7NO2S - PubChemL-cysteine is an optically active form of cysteine having L-configuration.It has a role as a flour treatment agent,a human metabolite and an EC 4.3.1.3 ( histidine ammonia -lyase) inhibitor.It is a serine family amino acid,a proteinogenic amino acid,a cysteine and a L-alpha-amino acid.

MYC-Induced Cancer Cell Energy Metabolism and

Although cancers have altered glucose metabolism,termed the Warburg effect,which describes the increased uptake and conversion of glucose to lactate by cancer cells under adequate oxygen tension,changes in the metabolism of glutamine and fatty acid have also been documented.The MYC oncogene,which contributes to the genesis of many human cancers,encodes a transcription factor cMetabolic Reprogramming in Brain Tumors Annual ReviewNext-generation sequencing has substantially enhanced our understanding of the genetics of primary brain tumors by uncovering several novel driver genetic alterations.How many of these genetic modifications contribute to the pathogenesis of brain tumors is not well understood.An exciting paradigm emerging in cancer biology is that oncogenes actively reprogram cellular metabolism toMetabolic reprogramming the emerging concept and Oct 06,2015·Tumor heterogeneity in regard to mitochondrial metabolism,in seeming contradiction to the Warburg effect,is considered to induce the diversity in activated metabolic pathways (Fig.2).Notably,MRD in several kinds of cancers is enriched in CSCs,leading to intra-tumoral heterogeneity and poor prognosis [ 1 ,9 ,10 ,37 ].

Metabolism - Journal - Elsevier

Metabolism Open is a new,peer-reviewed,fully open-access sister journal to Metabolism,both publishing original research and reviews related to all aspects of human metabolism.Articles considered for publication include studies in humans,animal and cellular models.Methylglyoxal possible link between hyperglycaemia and Aug 26,2009·No matter the cause of diabetes,the result is always hyperglycaemia.This excess glucose metabolism drives several damage pathways and raises concentrations of the reactive dicarbonyl,methylglyoxal (MG).MG can modify the structure and function of target molecules by forming advanced glycation end-products (AGEs) that act through their receptor (RAGE) to perpetuateModification of -Defensin-2 by Dicarbonyls Methylglyoxal Aug 05,2015·Background Beta-defensins (hBDs) provide antimicrobial and chemotactic defense against bacterial,viral and fungal infections.Human -defensin-2 (hBD-2) acts against gram-negative bacteria and chemoattracts immature dendritic cells,thus regulating innate and adaptive immunity.Immunosuppression due to hyperglycemia underlies chronic infection in Type 2 diabetes.

Myristoleic acid produced by enterococci reduces obesity

Objective Dietary fibre has beneficial effects on energy metabolism,and the majority of studies have focused on short-chain fatty acids produced by gut microbiota.Ginseng has been reported to aid in body weight management,however,its mechanism of action is not yet clear.In this study,we focused on the potential modulating effect of ginseng on gut microbiota,aiming to identify specific N-acetylcysteine and taurine prevent hyperglycemia-inducedOct 01,2003·On the other hand,glucose metabolism results in the formation of reactive 3-carbon metabolites such as glyoxal and methylglyoxal,which,by more rapid nonenzymatic protein glycation,may generate ROS and protein carbonyls (6,33,37,84).Another source ofNutriomics - Nutrition and Obesities Systemic ApproachesNov 18,2020·Publications.Contact.Nutrition and Obesities Systemic Approaches.Laboratory headed by Prof K.Clement.Our laboratory is conducting for many years basic and translational research in the area of obesity and related metabolic disorders.Genetic determinants are strong contributors of early onset and severe obesity but in commoner forms

Obesity and type-2 diabetes as inducers of premature

Jul 27,2018·High glucose levels associated with diabetes have also been shown to promote EC senescence in vitro.Culturing HUVECs under high glucose was shown to induce HUVEC senescence and is again associated with a reduction in NO synthesis (Zhong et al.2010).Oxidative stress mediated by lipid metabolism contributes Jan 01,2019·We reported that ARPE-19 exposed to 25mM glucose for 48h did not induce apoptosis,but senescence validated by SA--Gal staining,p21 expression and cell cycle distribution.High glucose also increased oxidant species that exerted a pivotal role in senescence,which could be relieved by the treatment with antioxidant N-acetylcysteine (NAC).People also askHow does high glucose cause RPE cell senescence?How does high glucose cause RPE cell senescence?Early high glucose exposure induces RPE cell senescence rather than apoptosis.Fatty acid synthesis induced by high glucose through PI3K/AKT/mTOR pathway leads to lipid accumulation.Lipid oxidation contributes to high glucose-induced RPE senescence by accumulating oxidant species.Oxidative stress mediated by lipid metabolism contributes

Plant organ senescence regulation by manifold pathways

The metabolism of PA during senescence is linked to many intracellular metabolic pathways,including signalling molecules and metabolites that are associated with cellular responses to environmental changes (SobieszczukNowicka 2017).The findings indicate that the internal pool of PAs undergoes regulation in senescing leaves.Professor TSAO,George Sai Wah - Academic Staff mTORC2-mediated PDHE1 nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma.Oncogene.2019 Jun;38(24):4669-4684.doi 10.1038/s41388-019-0749-y.Rapamycin and Glucose-Target of Rapamycin (TOR) Protein Background Plants possess conserved TOR PK but appear to display rapamycin resistance.Results Rapamycin effectively inactivates Arabidopsis TOR PK and retards glucose-mediated growth.Conclusion Integrative analyses with TOR-S6K phosphorylation,rapamycin,and estradiol-inducible tor and fkp mutants unravel the central roles of glucose-TOR signaling in diverse plant cells

Regulation of Leaf Senescence by Cytokinin,Sugars,and

The aim of this study was to investigate the interactions between cytokinin,sugar repression,and light in the senescence-related decline in photosynthetic enzymes of leaves.In transgenic tobacco ( Nicotiana tabacum ) plants that induce the production of cytokinin in senescing tissue,the age-dependent decline in NADH-dependent hydroxypyruvate reductase (HPR),ribulose-1,5-bisphosphate Role and mechanisms of autophagy in lung metabolism and Autophagy can promote glucose uptake in lung epithelial cells,thereby increasing the intracellular glucose metabolism process .We speculate that pyruvate produces lactic acid under anaerobic conditions,and the accumulation of large amounts of lactic acid accelerates the apoptosis of alveolar epithelial cells in IPF [ 159 ,160 ] (Fig.5 ).Some results are removed in response to a notice of local law requirement.For more information,please see here.12345NextT Cell Senescence Is Involved in the Disruption of Glucose Cellular senescence is an important contributing cause of aging.Senescent cells accumulate with age and secrete a potent mix of molecules and vesicles,the senescence associated secretory phenotype.This disrupts tissue function in a range of ways,and produces chronic inflammation that accelerates the progression of all of the common age-related conditions.All forms of

Some results are removed in response to a notice of local law requirement.For more information,please see here.Previous123456NextStem cell metabolism in tissue development and aging

Metabolism in pluripotent stem cells.(A) Glucose flux increases with the increase in GLUT1/3 expression,and the hexokinase (HK) and phosphofructokinase 1 (PFK1) enzymes become activated to sharply increase glycolytic flux.As a result,flux into the pentose phosphate pathway (PPP) for nucleotide synthesis increases.T cell metabolism drives immunity Journal of It was also recently shown that glucose metabolism is critical for CD4 memory T cell survival,and this is controlled by Notch signaling (Maekawa et al.,2015).The requirement for FAS in CD8 memory T cells is supported by a recent study showing that glycerol import into the cell via IL-7induced aquaporin-mediated transport is required for

T cells with dysfunctional mitochondria induce

Jun 19,2020·Mitochondrial dysfunction in various tissues is a prominent characteristic of age-related deterioration,but it is unclear how mitochondrial dysfunction in particular cell types contributes to this process.Desdín-Micó et al.generated mice with T cells that were specifically deficient in a mitochondrial DNAstabilizing protein.These animals exhibited multiple features associated with The Critical Role of Methylglyoxal and Glyoxalase 1 in The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).MG is the precursor of quantitatively important advanced glycation end products (AGEs) of protein and DNA- and MG-derived AGEs increase in experimental and clinical diabetes (3,4).The Role of Ceramides in Diabetes and Metabolic Health ·Adaptive regulation of glucose transport,glycolysis and respiration for cell proliferation Adaptive regulation of glucose transport,glycolysis and respiration for cell proliferation Toyoda,Yusuke; Saitoh,Shigeaki 2015-12-01 00:00:00 The cell must utilise nutrients to generate energy as a means of sustaining its life.As the environment is not necessarily abundant in nutrients and

Title Director,Client Relations at evitriaLocation Region Midtjylland,DanmarkThe Critical Role of Methylglyoxal and Glyoxalase 1 in

The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).MG is the precursor of quantitatively important advanced glycation end products (AGEs) of protein and DNA- and MG-derived AGEs increase in experimental and clinical diabetes (3,4).Ubiquinol-10 Supplementation Activates Mitochondria May 09,2014·Aim The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1 (SAMP1) mice.Results Here,we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members,which results in theUnderstanding the Warburg Effect The Metabolic May 22,2009·Glucose withdrawal induces cell death in a manner indistinguishable from that seen upon withdrawal of growth factor signaling,a phenomenon that may contribute to oncogene addiction .Indeed,where it has been examined in cancer patients,response to therapy is predicted by the ability to disrupt glucose metabolism as measured by FDG-PET

Main Steel Grades

The main products are carbon steel, wear plate, alloy steel, shipbuilding steel, hot/cold rolled steel, boiler steel, mild steel, seamless steel pipe, according to Americal standard ASTM, Japanese standard JIS, German standard DIN, EN, etc.

OUR FACTORY

Our mill has three steel plates production lines and Machining Platform

STEEL PLATE PRODUCTION LINE

STEEL PLATE PRODUCTION LINE

STEEL PIPE PRODUCTION LINE

STEEL PIPE PRODUCTION LINE

STEEL COIL PRODUCTION LINE

STEEL COIL PRODUCTION LINE

STEEL MACHINING CENTER

STEEL MACHINING CENTER

Contact Us

We are gradually formed four major advantageous products: steel plate, steel pipe, stainless steel, special steel, and established our own Machining processing center in order to meet customer's diverse requirements.

Welcome to contact us through online consulting, emails and hotline if you are interested in our company or products. Our staff will reply you within 24 hours.

  • E-mail: [email protected]
  • Tel: 0086-13569929107
  • Address: 50 Guohuai Road, Henan Province, China

Leave a Message